Hyperthyroidism: Causes, Symptoms & Treatment

Guide to hyperthyroidism: understand Graves' disease, thyroiditis, and treatment options including antithyroid drugs and radioactive iodine.

10 min readLast updated: 2026-02-17

Quick Facts

Prevalence
Affects 1-2% of the population
Main Cause
Graves' disease accounts for 70-80% of cases
Gender
More common in women

What Is Hyperthyroidism?

Hyperthyroidism is a condition in which the thyroid gland produces excess thyroid hormones, causing metabolic rate to increase significantly. This accelerates nearly all body functions, including heart rate, digestion, and heat production. The condition can range from mild to severe and may cause serious cardiac complications if untreated.

Graves' disease is the most common cause, accounting for approximately 70-80% of hyperthyroidism cases.

Key Info
Hyperthyroidism can cause heart palpitations, tremors, and anxiety. Thyroid storm is a rare but serious complication requiring emergency treatment.

Causes and Risk Factors

Main causes include:

  • Graves' disease (autoimmune)
  • Thyroiditis (inflammation)
  • Toxic nodules
  • Excessive iodine intake
  • Thyroid hormone medication overuse

Risk factors include female gender, family history, stress, and infection.

Symptoms

Symptoms develop gradually and include:

  • Rapid or irregular heartbeat
  • Tremors (especially in hands)
  • Anxiety and irritability
  • Heat intolerance and excessive sweating
  • Weight loss despite good appetite
  • Weakness and fatigue
  • Frequent bowel movements
  • Eye problems (in Graves' disease)

Diagnosis

Diagnosis involves:

  • TSH measurement (low in hyperthyroidism)
  • Free T4 and T3 levels (elevated)
  • Thyroid antibodies (TSI and TPO)
  • Thyroid uptake scan
  • Ultrasound
Clinical Note
A suppressed TSH with elevated free T4 or T3 confirms hyperthyroidism. Additional testing helps determine the cause.

Treatment and Management

Treatment options include:

  • Antithyroid medications (PTU, methimazole)
  • Beta-blockers for symptom relief
  • Radioactive iodine therapy
  • Thyroid surgery
  • Iodine solution (Lugol's or SSKI)

Choice depends on age, pregnancy status, severity, and cause.

Warning
Thyroid storm is a rare medical emergency presenting with high fever, severe tachycardia, and altered consciousness. This requires immediate hospitalization.

Prevention

While Graves' disease cannot be prevented, stress reduction may help manage symptoms. Avoiding iodine excess and careful medication dosing prevent iatrogenic hyperthyroidism.

When to See a Doctor

Seek care for palpitations, severe tremors, or chest pain. Regular monitoring during treatment is essential. Immediate care is needed for signs of thyroid storm.

Medically reviewed by

Medical Review Team, Endocrinology

Last updated: 2026-02-17Sources: 2

The content on Medical Atlas is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider.