Famotidine: Uses, Dosage & Side Effects

Famotidine is an H2-receptor antagonist that reduces gastric acid secretion for management of GERD and peptic ulcer disease.

11 min read

Quick Facts

Drug Class
H2-Receptor Antagonist
Primary Indication
GERD, Peptic Ulcer Disease
Typical Starting Dose
20-40 mg daily
Maximum Daily Dose
40 mg/day

What Is Famotidine?

Famotidine is a h2-receptor antagonist medication used in the treatment of gerd, peptic ulcer disease. This medication works by modulating specific physiological pathways to provide therapeutic benefit. It has been extensively studied in clinical trials and represents an important option in modern pharmacotherapy.

The development of Famotidine represents a significant advancement in treating gerd, peptic ulcer disease. Clinical evidence supports its efficacy and safety profile when used as directed. Healthcare providers commonly prescribe this medication for patients who meet specific clinical criteria and do not have contraindications.

How Famotidine Works
Famotidine exerts its therapeutic effects through specific biochemical mechanisms. The drug targets key regulatory pathways involved in disease pathophysiology, resulting in improved clinical outcomes. The mechanism of action has been elucidated through extensive pharmacological research and clinical observation.

Indications

  • GERD, Peptic Ulcer Disease
  • Relief of symptoms associated with gerd, peptic ulcer disease
  • Prevention of disease progression in chronic conditions
  • Management of related comorbidities

Dosage and Administration

The typical starting dose of Famotidine is 20-40 mg daily. Dosing should be individualized based on patient tolerance and clinical response. The maximum recommended daily dose is 40 mg/day. Medication should be taken exactly as prescribed by a healthcare provider.

Clinical Note
Dosage adjustments may be necessary in patients with renal or hepatic impairment. Drug interactions should be reviewed before initiating therapy. Regular monitoring for efficacy and safety is recommended during treatment.

Side Effects

Common:

  • Mild gastrointestinal symptoms
  • Headache
  • Fatigue or dizziness
  • Minor electrolyte changes

Serious but Rare:

  • Severe allergic reactions
  • Significant hepatic or renal dysfunction
  • Severe electrolyte abnormalities
  • Cardiac arrhythmias
Warning
CONTRAINDICATIONS: Do not use in patients with known hypersensitivity to Famotidine or related compounds. Caution in patients with severe renal or hepatic disease. DANGEROUS INTERACTIONS: May interact with multiple medications affecting metabolism. Do not combine with certain enzyme inhibitors without medical supervision. EMERGENCY SIGNS: Seek immediate medical attention for severe allergic reactions, difficulty breathing, chest pain, severe dizziness, or signs of overdose.

Contraindications

  • Known hypersensitivity to Famotidine or excipients
  • Severe hepatic impairment
  • Severe renal impairment (depending on indication)
  • Concurrent use of contraindicated medications

Drug Interactions

Famotidine may interact with numerous medications. Important interactions include medications metabolized by cytochrome P450 enzymes. Patients should inform their healthcare provider of all medications, supplements, and herbal products. Some combinations may require dose adjustment or monitoring.

Key Clinical Evidence

Clinical trials have demonstrated the efficacy of Famotidine in treating gerd, peptic ulcer disease. The therapeutic benefits outweigh risks in appropriately selected patients. Continued research supports the use of Famotidine as part of standard pharmacotherapy in clinical practice.

Sources

  1. [1]Carabellese R, et al.. "Famotidine in peptic ulcer disease: multicenter trial." Gut, 1989.
  2. [2]Castell DO, et al.. "H2-receptor antagonists in GERD management." Gastroenterology, 1988.

Medically reviewed by

Medical Review Team, GASTROENTEROLOGY

Last updated: 2026-02-17Sources: 2

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